Leiter
apl. Prof. Dr. rer. nat. Jörg Bock
Zoologie/Entwicklungsneurobiologie
Completed projects
Adaptive plasticity of brain structure and function in response to consecutive stress exposure: assessing the role of endocannabinoid receptors as mediators of resilience
Duration: 01.03.2020 to 31.01.2025
The major aim of this project is to unravel neurobiological, cellular, molecular, and epigenetic events that mediate the development of stress resilience versus stress vulnerability in a rat model of early life stress (ELS). The overarching hypothesis is that vulnerable as well as resilient individuals exist and that exposure to ELS (1st hit) induces different or contrasting adaptive plasticity processes in the respective animals. We will test if repeated exposure to stress at different stages of development, ELS as 1st "hit” and swim stress at juvenility as 2nd "hit” will have lasting effects on neuronal networks in the brain, specifically those mediating affect regulation and social approach and reward. More specifically, we will analyze if rats classified as resilient or susceptible following the 1st hit and subsequently exposed to a 2nd hit at juvenility will demonstrate the same phenotype at adulthood, that is, resilient animals will remain resilient throughout the lifespan, whereas susceptible animals may display exacerbation of symptoms following the 2nd hit (cumulative stress concept).
On the mechanistic level we will address two complementary hypotheses of ELS-induced brain plasticity. First, we hypothesize that a) the mPFC-amygdala-NAc circuit is central in understanding vulnerability vs resilience due to its continuous and significant maturation during juvenility ; b) the long-term effect of ELS-induced "stress-inoculation” vs vulnerability is sex-specific and is conferred c) by activity-induced changes in the expression of synaptic plasticity proteins within specific neuronal ensembles, which confer d) structural long-term changes in synaptic connectivity and plasticity. Second, we hypothesize that ELS-induced resilience is conferred e) by changes in CB1 receptors, whose expression f) is epigenetically re-programmed by ELS. Finally, the project will also elucidate if and in which way pharmacological interventions on the endocannabinoid system may be effective in normalizing behavioral pathology and in epigenetic "reprogramming” of ELS-induced brain functions.
This multidisciplinary project is essential in order to disentangle the factors that moderate the long-term effects of ELS, which is crucial for identifying the biological underpinnings of resilience and characterizing neural circuits and molecular pathways involved in (re-)programming mechanisms.
Inter- and transgenerational consequences of early life adversity on oxytocin-receptor gene expression
Duration: 01.07.2020 to 31.01.2025
Experience-driven maturation of neuronal and behavioral functions represents a fundamental principle of functional brain development. During brain development, genetically preprogrammed events interact with environmental and psychological ‘epigenetic’ factors, which results in ‘fine-tuning’ of neuronal networks in order to adapt to an individual´s environment and to generate appropriate responses to environmental challenges. Studies in humans as well as in various animal models have shown that the exposure to one or multiple forms of early-life adversity (ELA), such as childhood stress, abuse and neglect, constitutes a major risk factor for developing somatic and behavioral disorders and in the etiology of a wide range of mental diseases. Increasing evidence, including those from our own studies, demonstrated that negative and positive environmental early-life experiences critically interfere with the maturation of brain structure and function . Hence, synaptic circuitries adapt or maladapt to a given environment, which - in the case of adverse experiences such as socio-emotional neglect, abuse, and trauma - can lead to dysfunctional neuronal circuitries, and thereby contribute to the aetiology of mental and behavioral disorders. Moreover, evidence is emerging that behavioral and brain structural/functional consequences of ELA can be transmitted to the next generations, however, the detailed mechanisms underlying inter- and transgenerational transmission of ELA are still poorly understood.
Based on these findings the aim of this project is to compare the inter- and transgenerational transmission of ELA-induced changes in behavior and in prefrontal and hippocampal Oxytocin-receptor (OxtR) expression, including the underlying epigenetic regulation, in male and female offspring (F1 and F2 generation) of stress-exposed mothers (F0 generation).
We expect that the brain of individuals, which were exposed to ELA, suffers from dysfunctional neuronal circuits in prefrontal and hippocampal areas, which hinders their behavioral flexibility and adaptations to the environment. We will focus on the oxytocinergic system (specifically the expression of the OxtR) based on our previous investigations, where we observed a) depressive-like and ADHD-like behavioral phenotypes in ELA animals, b) impaired maternal care behavior in ELA females (F0 generation) towards their offspring (F1 generation) and c) decreased OxtR gene-expression in the PFC of ELA exposed F0 females. We will address the working hypothesis (a) that the ELA induced decrease in OxtR gene expression in the brain and oocytes of adult female mice (F0 generation) is a) epigenetically regulated and b) transmitted to their F1 and F2 offspring via © maternal behavior and/or (d) via the maternal germline.
Epigenetic programming of early life stress on stress response at adulthood: the role of NPY receptors as mediators of mental health and disease
Duration: 01.01.2021 to 31.12.2022
Early life adversity and early life stress (ELS) constitute major risk factors that contribute to the aetiology of various psychiatric disorders which emerge during puberty and adulthood. The vast majority of animal studies on ELA have studied the impact of a single brief or chronic stress episode during defined developmental time windows. However, in "normal” life individuals "collect” many experiences of stress, trauma and neglect throughout life. Using an animal model of consecutive stress exposure (neonatal, periadolescent, adult) in mice we address the following questions: Do consecutive stressors during critical developmental phases accumulate and potentiate their effects and thereby increase the risk for the development of mental disorders? Or can consecutive ELS episodes induce adaptive neuronal and behavioral changes making an individual resilient towards an adverse environment later in life? We hypothesize that ELS can programm the expression of NPY-receptors in limbic and prefrontal brain areas via epigenetic mechanisms and thereby influencing stress response at later life periods. Thus, we will assess epigenetic changes (DNA-methylation, histone-modifications) at the promoter regions of NPY-receptors that may influence gene expression changes in response to single or consecutive stress exposure. Another focus of this project will be on potential sex-specific differences in susceptibility and resilience.
Adaptive plasticity of brain structure and function in response to consecutive stress exposure: assessing the role of endocannabinoid receptors as mediators of resilience
Duration: 01.09.2019 to 31.03.2021
Early life adversity and early life stress (ELS) constitute major risk factors that contribute to the aetiology of various psychiatric disorders which emerge during puberty and adulthood. The vast majority of animal studies on ELA have studied the impact of a single brief or chronic stress episode during defined developmental time windows. However, in "normal” life individuals "collect” many experiences of stress, trauma and neglect throughout life. Hence, in a "top-down” approach using an animal model of consecutive stress exposure (neonatal and periadolescent) we will address questions including: do consecutive stressors during critical developmental phases accumulate and successively potentiate their effects and thereby increase an individual´s vulnerability, resulting in severely dysfunctional brain and behavior? Or can consecutive ELS episodes entrain brain plasticity and behavior to make an individual resilient and better cope with an adverse environment later in life ("stress inoculation”)? On the mechanistic level we will address two complementary hypotheses of ELS-induced brain plasticity. First, we hypothesize that a) the mPFC-amygdala-n.accumbens circuit is central in understanding vulnerability vs resilience due to its continuous and significant maturation during juvenility (i.e. time point of our 2nd Hit); b) the long-term effect of ELS-induced "stress-inoculation” vs vulnerability is conferred by activity-induced changes in the expression of synaptic plasticity proteins within specific neuronal ensembles, which confer c) structural long-term changes in synaptic connectivity, neuronal function and plasticity, and d) that sex-specific differences exist. Second, we hypothesize that ELS-induced resilience is conferred e) by changes in endocannabinoid CB1 receptors, whose expression f) is epigenetically re-programmed by ELS. Using Chip sequencing we will screen for novel gene targets, including potential proteins, which are part of CB1-activated downstream signaling cascades. On the therapeutic level we will also elucidate if and in which way pharmacological interventions "normalize” behavioral pathology and ELS-induced changes in neuronal and synaptic function and plasticity brain. Since - despite the fact that many clinical investigations provide ample evidence for a considerable sex bias in the prevalence of ELS-induced mental disorders - the vast majority of research in animal models has focused on the analysis of males, another focus of this project will be laid on sex-specific differences in susceptibility and resilience.
Epigenetic reprogramming of glutamate-mediated mTOR pathways in the anteroventral cingulate cortex of suicide victims
Duration: 01.11.2019 to 31.03.2021
Suicide is an increasing public health problem, causing almost half of all violent deaths and resulting in almost one million fatalities in the world every year. It is of paramount importance to gain a comprehensive understanding of the brain mechanisms underlying the pathogenesis and pathophysiology of suicidal behavior, as well as to identify potential therapeutically relevant biomarkers in peripheral cells, in order to generate science-based, individually tailored protective and therapeutic interventions. We will address our working hypothesis that suicide may result from reduced neuronal activity and impaired synaptic plasticity, which constricts an individual´s competence to adequately and flexibly adapt to the environment. Besides specific genetic predispositions, evidence emerges that epigenetic mechanisms are also critically involved in the etiology of suicidal behavior. In postmortem human anterior cingulate cortex (from suicide victims and sudden-death controls archived in the Polish Suicide Brain Bank) the following hypotheses will be addressed: 1) is impaired neuronal activity in the suicidal brain associated with reduced rDNA transcriptional activity? 2) Is the reduced rDNA transcriptional activity caused by decreased mTOR expression, due to 3) reduced NMDA receptor expression/activation? 4) Is impaired synaptic plasticity associated with reduced synthesis of the synaptic plasticity protein Arc, as result of reduced mTOR expression? 5) Is the expected reduction in Arc expression related to long-term neuromorphological changes (dendrites, spine synapses)? 6) Is mTOR downregulation regulated via DNA hypermethylation? The added value of this project lies in the interdisciplinary and complementary experimental approaches, where different methodologies (AgNOR histology, mRNA expression/qPCR, DNA methylation analysis, 3D neuromorphology), are applied in tissue of the same individuals and thereby allows to correlate all biological parameters with each other and with the medical history of the individuals, and to create a multifaceted concept of the neurobiological changes in the suicidal brain.
Consequences of early life adversity (ELA) on cardiac oxytocin receptor expression: epigenetic regulation
Duration: 01.01.2019 to 31.03.2021
The impact of two paradigms for early life adversity (ELA are compared, long- (LTSS) and short-term separation stress (STSS) on Oxtr gene expression in cardiac muscle is analyzed including epigenetic regulatory mechanisms.
Inter- and transgenerational consequences of early life adversity on oxytocin-receptor gene expression
Duration: 01.11.2019 to 31.03.2021
Exposure to one or multiple forms of early-life adversity (ELA) constitutes a major risk factor for developing somatic and behavioral disorders and in the etiology of a wide range of mental disorders. On the other hand there is also evidence that ELA exposure may lead to stress resilience. In our animal model for ELA behavioral profiling of offspring of ELA-exposed mothers will identify vulnerable and resilient individuals in which epigenetic and transcriptomic changes will be compared. Evidence is emerging that behavioral and brain structural/functional consequences of ELA can be transmitted to the next generations, however, the detailed mechanisms underlying inter- and transgenerational transmission of ELA are still poorly understood. In our animal model for ELA we will attempt to unveil causal relationships between ELA exposure, behavioral dysfunctions, changes in gene expression and underlying epigenetic modifications in brain and other organs/cells. So far, various genes in particular those integrated in HPA functions, have been identified, whose expression is altered in response to ELA. However, ELA-induced changes in gene transcription are much more complex and most likely affect specific cellular, physiological and biochemical signaling pathways, which are involved in developmental and adult synaptic plasticity. Based on our findings one aim of this project is guided by a hypothesis-driven approach and will assess i) whether changes of OxtR gene expression, which we observed in ELA exposed F0 mothers are transmitted to the next (F1, F2) generations, and ii) if these changes are epigenetically regulated via DNA-methylation. Considering transgenerational epigenetic inheritance via the maternal line in mammals and in particular human populations, we will also identify ELA transmission paths, i.e. if transmission is mediated via behavioral maternal traits or through epigenetic changes in oocytes.
To expand our knowledge on ELA-induced changes in gene expression, another aim of this project is to conduct a whole genome transcriptome analysis to i) further identify ELA-induced changes in genes encoding proteins that are part of OxtR-related intracellular signaling cascades and ii) to detect novel gene targets which are affected by ELA.
Most of what is known about the effects of ELA on brain development arises from experimental studies in male individuals, which is somewhat surprising in view of the considerable sex-bias in the prevalence of ELA-induced disorders. Consequently, another aim of this project is to deepen our knowledge about sex-specific effects of ELA and to characterize sex as vulnerability or resiliency factor.
Early life stress reprograms DARPP-32 signaling and determines behavioral pathology and resilience
Duration: 01.01.2019 to 31.03.2021
Major depressive disorder (MDD) is one of the most disabling and potentially life-threatening diseases. The lifetime prevalence of MDD is 15-20%, and women suffer from MDD about twice more often than men. MDD is a complex multifactorial disorder, with both genetic and environmental factors playing an important role in its development. Despite decades of research and efforts to collect cohorts for genetic studies, we still lack a fundamental understanding of the pathophysiology for any of the classical psychiatric disorders, including MDD. Although heritability is estimated to be approximately 37%, DNA sequence variations cannot fully explain the susceptibility to MDD, exposure to known environmental risk factors, such as early life adversity (ELA), also significantly contribute to the aetiology of MDD. It is widely accepted that early life adversities (ELA) such as stress, trauma, abuse and neglect are critical risk factors contributing to the aetiology various mental disorders including major depressive disorder and suicidal behavior. This project is guided by the hypotheses that
· exposure to early life adversity (ELA) such as early life stress induces - depending on the duration of stress exposure - either stress vulnerability or stress resilience;
· ELA exposure induces epigenetically regulated changes in the expression of genes encoding proteins that are critically involved in synaptic plasticity, and
· resilient individuals display elevated synaptic plasticity, which enables them to better cope with stress challenges and to continuously adapt to environmental changes;
· vulnerable individuals show reduced synaptic plasticity ,which impairs stress coping and the competence to adapt to the environment.
Since in human patients the level of analysis is limited to peripheral cells or to postmortem brain tissue, we have established animal models, in which peripheral and brain tissue can be analyzed in parallel, as well as other body organs, e.g. to unveil potential comorbidities
Trauma-induced transgenerational epigenetic programming of modulatory transmitter systems
Duration: 01.02.2013 to 01.07.2016
Early childhood traumatic experiences, such as disorders of mother-child interaction, are associated with long-term, often even transgenerational behavioral disorders. Epigenetic changes, which influence the gene expression potential of certain genes in interaction with environmental factors and thus control neuronal adaptation processes, are discussed as causal mechanisms for the development of these disorders.
An animal experimental approach is used to investigate which epigenetic mechanisms contribute to the transgenerational transmission of early stress experiences. Repeated maternal separation in mice serves as a model for this. Our working hypothesis postulates that these early trauma experiences lead to region-specific changes in modulatory transmitter receptors that are epigenetically regulated and can be transmitted to the offspring.
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Active avoidance learning in young and adult mice: behavioral studies and functional imaging (2-fluorodeoxyglucose)
Duration: 01.01.2012 to 30.04.2016
This project investigates the ontogenesis of negative feedback learning and whether early childhood learning experiences influence learning performance in later life. We postulate that, depending on the timing of the early childhood learning experience, there is either a reduction (learning blockade) or an improvement in learning performance in adulthood. The project includes behavioral analyses and functional imaging to analyze learning-specific neuronal networks.
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Paternal behavior and metabolic brain activity during fatherhood in Octodon degus
Duration: 01.01.2015 to 31.03.2016
This project aims to investigate the specific role of the father in the development of his offspring. The project includes behavioral analyses of paternal behavior and functional imaging to measure brain activity in order to identify neural circuits specifically associated with paternal behaviors.
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Understanding and Breaking the Intergenerational Cycle of Abuse: Epigenetic mechanisms underlying perinatal stress (PNS)-induced transgenerational structural synaptic changes in prefronto-limbic-hypothalamic (PLH) circuits
Duration: 01.06.2012 to 31.05.2015
A number of animal studies throughout the last decades, including ours, which induced chronic or repeated perinatal stress (e.g. maternal separation) to mimic human early childhood trauma and neglect, revealed that the maturation of neuronal pathways and socio-emotional behaviour is altered in these animals . So far, neither the brain functional, nor the epigenetic mechanisms underlying these trauma-induced neuronal and behavioural changes are understood and thus will be one focus of our project. Epigenetics is most commonly defined as the ensemble of heritable alterations in gene functions, that cannot be explained by changes in the DNA sequence itself. At the molecular level, epigenetic mechanisms are modifications of the DNA and histone proteins, the major constituents of chromatin. These mechanisms include direct modifications of the DNA, i.e. through DNA-methylation and specific modifications of histone proteins (i.e. acetylation, phosphorylation, methylation). Depending on the type of modification this can result in actively transcribed or silenced genes, and this strongly influences neuronal and synaptic development in the juvenile brain. There is increasing evidence that these changes affect higher cognitive functions and emotionality and that epigenetic factors mediate the relationship between early life experiences and the long-term behavioural outcome. The first focus of this project is to test the hypothesis that maternal care interferes with the functional maturation of prefronto-limbic-hypothalamic (PLH) pathways. Functionality of PLH pathways of traumatized animals will be assessed using functional imaging techniques (2-FDG, SPECT), which are established in our lab and which allow to monitor brain activity in awake, freely behaving animals. In direct correspondence to clinical projects of this network a modified version of an emotion recognition task used in the clinical studies will be applied as well as an acute stress challenge. Preliminary functional imaging experiments revealed that traumatized infant and preadolescent animals, display significantly reduced activation in prefrontal and limbic brain regions. The second focus will address the hypothesis that the brain functional and structural changes are induced by epigenetic alterations, evoked by changes in maternal care. First, DNA-methylation profiles on the promoters of 5-HTT and GR will be analyzed from samples of oral mucosa, which can be directly compared with the results of the clinical projects. In our lab we will search for histone modifications affecting other targets, including oxytocin, dopamine-receptors (DAR) and dopaminetransporters (DAT), egr-1 and arc/arg3.1.
UBICA: Understanding and Breaking the Intergenerational Cycle of Abuse
Duration: 01.06.2012 to 31.05.2015
A number of animal studies throughout the last decades, including ours, which induced chronic or repeated perinatal stress (e.g. maternal separation) to mimic human early childhood trauma and neglect, revealed that the maturation of neuronal pathways and socio-emotional behaviour is altered in these animals . So far, neither the brain functional, nor the epigenetic mechanisms underlying these trauma-induced neuronal and behavioural changes are understood and thus will be one focus of our project. Epigenetics is most commonly defined as the ensemble of heritable alterations in gene functions, that cannot be explained by changes in the DNA sequence itself. At the molecular level, epigenetic mechanisms are modifications of the DNA and histone proteins, the major constituents of chromatin. These mechanisms include direct modifications of the DNA, i.e. through DNA-methylation and specific modifications of histone proteins (i.e. acetylation, phosphorylation, methylation). Depending on the type of modification this can result in actively transcribed or silenced genes, and this strongly influences neuronal and synaptic development in the juvenile brain. There is increasing evidence that these changes affect higher cognitive functions and emotionality and that epigenetic factors mediate the relationship between early life experiences and the long-term behavioural outcome. The first focus of this project is to test the hypothesis that maternal care interferes with the functional maturation of prefronto-limbic-hypothalamic (PLH) pathways. Functionality of PLH pathways of traumatized animals will be assessed using functional imaging techniques (2-FDG, SPECT), which are established in our lab and which allow to monitor brain activity in awake, freely behaving animals. In direct correspondence to clinical projects of this network a modified version of an emotion recognition task used in the clinical studies will be applied as well as an acute stress challenge. Preliminary functional imaging experiments revealed that traumatized infant and preadolescent animals, display significantly reduced activation in prefrontal and limbic brain regions. The second focus will address the hypothesis that the brain functional and structural changes are induced by epigenetic alterations, evoked by changes in maternal care. First, DNA-methylation profiles on the promoters of 5-HTT and GR will be analyzed from samples of oral mucosa, which can be directly compared with the results of the clinical projects. In our lab we will search for histone modifications affecting other targets, including oxytocin, dopamine-receptors (DAR) and dopaminetransporters (DAT), egr-1 and arc/arg3.1.
Epigenetische Histonmodifikationen in einem Tiermodell für Depression: Chromatin-Remodelling nach frühen Stresserfahrungen
Duration: 01.06.2011 to 31.07.2014
The general aim of this project is to unravel the epigenetic and molecular mechanisms underlying perinatal stress-induced dendritic and synaptic maturational changes in prefrontal and limbic brain regions, which are assumed to represent the neuronal substrate for stress-induced behavioral dysfunctions, including anxiety and depression. We will test the hypothesis that prenatal stress exposure induces chromatin remodeling, including changes in histone acetylation, which are assumed to play a key role in both the etiology and treatment of depression. We will focus on epigenetic modifications, which particularly affect gene expression and the synthesis of synaptic and cytoskeletal proteins, which are likely candidates to mediate the stress-induced dendritic and synaptic changes in the prefrontal cortex, hippocampus and the amygdala. Because many of the mental disorders associated with prenatal stress exhibit a sex bias, the molecular analysis of how sex-specific susceptibility arises will improve our mechanistic insight and lead to the identification of novel targets for protective and therapeutic development. Thus, another aim will be the identification sex-specific differences in chromatin remodeling in response to prenatal stress, which we assume to underlie the previously observed stress-induced sex-specific behavioral, molecular, dendritic and synaptic changes.
Influence of enriched environment and caloric restriction on pathology and mitochondrial parameters in Alzheimer mice
Duration: 01.11.2011 to 30.06.2014
Among the neurodegenerative changes of the central nervous system, Alzheimer's disease is the most common. As the risk of developing the disease increases with advancing age, it can be assumed that increasing life expectancy will lead to a dramatic rise in the number of cases in Europe and other parts of the world in the coming decades. In addition to causing considerable suffering, the disease also causes considerable economic damage due to the high level of care required. Although science favors a central role of Aß peptide overproduction in pathogenesis, initial attempts to exploit this mechanism therapeutically have been disappointing and the molecular biological details of pathogenesis remain unclear. This neural network uses novel mouse models to investigate the role of a chronic deficiency of the neurotrophic factor BDNF previously found in patients in the genesis of Alzheimer's disease, with particular emphasis on memory performance in multiple behavioral tests and considering a potential role of mitochondrial disorders associated with oxidative stress. Once sufficiently characterized, the disease models will later provide the basis for evaluating protective strategies, such as physical or cognitive stimulation, BDNF substitution, receptor agonists or deep brain stimulation.
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Developmental chromatin-remodelling in stress- and learning-induced neuronal plasticity
Duration: 01.01.2009 to 31.12.2012
Frühe Lern- und Erfahrungsprozesse beeinflussen in Interaktion mit genetisch festgelegten Programmen die funktionelle neuronale Entwicklung. Negativerfahrungen wie z.B. Stress können hierbei zu Fehlentwicklungen führen, eine Ursache für später auftretende Verhaltensdefizite. Chromatin-Remodellierung und Histonmodifikationen sind epigenetische Prozesse, die sowohl für die Etablierung als auch für die Aufrechterhaltung des konstanten Verhältnisses von aktiven und inaktiven Genen verantwortlich sind und somit vermutlich auch einen erheblichen regulatorischen Einfluss auf die neuronale Entwicklung ausüben. Bislang gibt es allerdings keinerlei Hinweise ob und welche epigenetischen Mechanismen durch frühe Stresserfahrungen induziert werden und somit auch keine Hinweise inwieweit diese Mechanismen mit stressinduzierten synaptischen Fehlentwicklungen in Zusammenhang stehen. Wir wollen daher in diesem Projekt der Frage nachgehen, ob frühe prä- und postnatale Stresserfahrungen zu Chromatin-Remodellierung und Histonmodifikationen führen und ob diese mit der funktionellen neuronalen Reifung in limbischen Arealen und der damit zusammenhängenden Entwicklung spezifischer Verhaltensweisen korrelieren.
- Braun, Prof. Dr. Katharina; Institut für Biologie
- Goldschmidt, Dr. Jürgen, Leibniz Institut Magdeburg
- Prof. Dr. Irit Akirav, University of Haifa
- Prof. Dr. Mouna Maroun, University of Haifa
2024
Abstract
Sex-specific and epigenetically mediated changes of CB1R expression in the medical prefrontal cortex in response to early life stress
Bock, Jörg; Portugalov, A.; Maroun, M.; Akirav, I.; Braun, Anna Katharina; Demaili, A.
In: FENS Forum 2024 - FENS, Artikel PS07-29AM-070
Book chapter
Perinatal epigenetic programming of functional brain circuits
Bock, Jörg
In: Epigenetics in Biological Communication , 1st ed. 2024. - Cham : Springer Nature Switzerland ; Witzany, Guenther, S. 197-218
Peer-reviewed journal article
Early life stress induces decreased expression of CB1R and FAAH and epigenetic changes in the medial prefrontal cortex of male rats
Demaili, Arijana; Portugalov, Anna; Maroun, Mouna; Akirav, Irit; Braun, Anna Katharina; Bock, Jörg
In: Frontiers in cellular neuroscience - Lausanne : Frontiers Research Foundation, Bd. 18 (2024), Artikel 1474992, insges. 15 S.
2023
Peer-reviewed journal article
Epigenetic (re)programming of gene expression changes of CB1R and FAAH in the medial prefrontal cortex in response to early life and adolescence stress exposure
Demaili, Arijana; Portugalov, Anna; Dudai, Michal; Maroun, Mouna; Braun, Anna Katharina; Bock, Jörg
In: Frontiers in cellular neuroscience - Lausanne : Frontiers Research Foundation, Bd. 17 (2023), Artikel 1129946, insges. 16 S.
Paternal deprivation and female biparental family rearing induce dendritic and synaptic changes in octodon degus: II. nucleus accumbens
Schultz, Tony; Braun, Anna Katharina; Bock, Jörg
In: Developmental neuroscience - Basel : Karger, Bd. 45 (2023), Heft 3, S. 147-160
2022
Book chapter
Neuronale Plastizität
Bock, Jörg
In: Selbstmanagement ressourcenorientiert/ Storch - Bern: Hogrefe; Storch, Maja *1958-* . - 2022, S. 67-86
Peer-reviewed journal article
Early life stress-induced epigenetic programming of hippocampal NPY-Y2 receptor gene expression changes in response to adult stress
Kocamaz, Derya; Franzke, Caroline; Gröger, Nicole; Braun, Anna Katharina; Bock, Jörg
In: Frontiers in cellular neuroscience - Lausanne : Frontiers Research Foundation, Bd. 16 (2022), Artikel 936979, insges. 12 S.
2021
Peer-reviewed journal article
Imaging of functional brain circuits during acquisition and memory retrieval in an aversive feedback learning task - single photon emission computed tomography of regional cerebral blood flow in freely behaving rats
Braun, Anna Katharina; Mannewitz, Anja; Bock, Jörg; Kreitz, Silke; Hess, Andreas; Scheich, Henning; Goldschmidt, Jürgen
In: Brain Sciences - Basel : MDPI AG, Bd. 11 (2021), Heft 5, Artikel 659, insges. 21 S.
Glucocorticoids attenuate interleukin6induced cFos and Egr1 expression and impair neuritogenesis in PC12 cells
Bongartz, Hannes; Seiß, Elena Anne; Bock, Jörg; Schaper, Fred
In: Journal of neurochemistry - Oxford: Wiley-Blackwell, Bd. 157 (2021), 3, S. 532-549
2020
Book chapter
Fetale Programmierung - Epigenetik
Bock, Jörg
In: Early Life Care: frühe Hilfen von der Schwangerschaft bis zum 1. Lebensjahr : das Grundlagenbuch / Karl Heinz Brisch, Wolfgang Sperl, Katharina Kruppa (Hrsg.): frühe Hilfen von der Schwangerschaft bis zum 1. Lebensjahr : das Grundlagenbuch - Stuttgart: Klett-Cotta, 2020 . - 2020, S. 55-83
Peer-reviewed journal article
Paternal deprivation and female biparental family rearing induce dendritic and synaptic changes in octodon degus : I. Medial prefrontal cortex
Tony, Schultz; Bock, Jörg; Braun, Anna Katharina
In: Frontiers in synaptic neuroscience - Lausanne: Frontiers Research Foundation, Volume 12(2020), article 38, 12 Seiten
Maternal separation induces long-term alterations in the cardiac oxytocin receptor and cystathionine γ-lyase expression in mice
Wigger, Daniela C.; Gröger, Nicole; Lesse, Alexandra; Krause, Sabrina; Merz, Tamara; Gündel, Harald; Braun, Anna Katharina; McCook, Oscar; Radermacher, Peter; Bock, Jörg; Waller, Christiane
In: Oxidative medicine and cellular longevity - Austin, Tex.: Landes Bioscience, Volume 2020(2020), article ID 4309605, 10 Seiten
2019
Book chapter
Neurobiologische und epigenetische Auswirkungen perinataler Stresserfahrungen auf die Entwicklung von Gehirn und Verhalten
Bock, Jörg
In: Familien unter Hoch-Stress: Beratung, Therapie und Prävention für Schwangere, Eltern und Säuglinge in Ausnahmesituationen / herausgegeben von Karl Heinz Brisch: Beratung, Therapie und Prävention für Schwangere, Eltern und Säuglinge in Ausnahmesituationen/ Familien unter Hoch-Stress: Beratung, Therapie und Prävention für Schwangere, Eltern und Säuglinge in Ausnahmesituationen / herausgegeben von Karl Heinz Brisch - Stuttgart: Klett-Cotta, 2019 . - 2019, S. 47-72[Literaturangaben]
Non-peer-reviewed journal article
Programmierung von Vulnerabilität und Resilienz durch perinatale Stresserfahrung
Bock, Jörg
In: Fiduz: Vertrauen, Zutrauen ; Infoblatt der Medizinischen Abteilung der Arbeitsstelle Frühförderung Bayern - München: Arbeitsstelle Frühförderung, 1998, Bd. 22.2019, 44, S. 10-12
2018
Peer-reviewed journal article
Early-life adversity induces epigenetically regulated changes in hippocampal dopaminergic molecular pathways
Köhler, Jana C.; Gröger, Nicole; Lesse, Alexandra; Guara Ciurana, Sonia; Rether, K.; Fegert, J.; Bock, Jörg; Braun, Anna Katharina
In: Molecular neurobiology - Totowa, NJ: Humana Press, 1987, Bd. 56.2018, 5, S. 3616-3625
Maternal stress during pregnancy induces depressive-like behavior only in female offspring and correlates to their hippocampal Avp and Oxt receptor expression
Schmidt, Michaela; Braun, Anna Katharina; Brandwein, Christiane; Rossetti, A. C.; Guara Ciurana, Sonia; Riva, M. A.; Deuschle, Michael; Bock, Jörg; Gass, Peter; Gröger, Nicole
In: Behavioural brain research: an international journal - Amsterdam: Elsevier, 1980, Bd. 353.2018, S. 1-10, insges. 10 S.[Gesehen am 30.03.2020; Available online 26 June 2018]
Infant avoidance training alters cellular activation patterns in prefronto-limbic circuits during adult avoidance learning: II. Cellular imaging of neurons expressing the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1)
Gröger, Nicole; Mannewitz, Anja; Bock, Jörg; Becker, Susann; Guttmann, Katja; Poeggel, Gerd; Braun, Anna Katharina
In: Brain structure & function - Berlin: Springer, Bd. 223.2018, 2, S. 713-725
Comparing brain activity patterns during spontaneous exploratory and cue-instructed learning using single photon-emission computed tomography (SPECT) imaging of regional cerebral blood flow in freely behaving rats
Mannewitz, A.; Bock, Jörg; Kreitz, S.; Hess, A.; Goldschmidt, J.; Scheich, H.; Braun, Anna Katharina
In: Brain structure & function - Berlin: Springer, 2007, Bd. 223.2018, 4, S. 2025-2038
2017
Peer-reviewed journal article
Chronic postnatal stress induces depressive-like behavior in male mice and programs second-Hit stress-induced gene expression patterns of OxtR and AvpR1a in adulthood
Lesse, Alexandra; Rether, Kathy; Gröger, Nicole; Braun, Anna Katharina; Bock, Jörg
In: Molecular neurobiology - Totowa, NJ : Humana Press, Bd. 54 (2017), Heft 6, S. 4813-4819
Experience-induced transgenerational (re-)programming of neuronal structure and functions - impact of stress prior and during pregnancy
Braun, Anna Katharina; Bock, Jörg; Wainstock, Tamar; Matas, Emmanuel; Gaisler-Salomon, Inna; Fegert, Jörg M.; Ziegenhain, Ute; Segal, Menahem
In: Neuroscience & biobehavioral reviews - Amsterdam [u.a.] : Elsevier Science, Bd. 117 (2020), S. 281-296
Einfluss früher Trennungs- und Stresserfahrungen auf die funktionelle Reifung des Gehirns
Braun, Anna Katharina; Poeggel, Gerd; Gos, Tomasz; Bock, Jörg
In: Leidfaden - Göttingen: Vandenhoeck u. Ruprecht, 2011, Bd. 6.2017, 4, S. 28-32
Early life stress induces attention-deficit hyperactivity disorder (ADHD)-like behavioral and brain metabolic dysfunctions - functional imaging of methylphenidate treatment in a novel rodent model
Bock, Jörg; Breuer, S.; Poeggel, Gerd; Braun, Anna Katharina
In: Brain structure & function - Berlin: Springer, 2007, Bd. 222.2017, 2, S. 765-780
Infant avoidance training alters cellular activation patterns in prefronto-limbic circuits during adult avoidance learning: I. Cellular imaging of neurons expressing the synaptic plasticity early growth response protein 1 (Egr1)
Gröger, Nicole; Mannewitz, Anja; Bock, Jörg; Schultz, Tony Fernando; Becker, Susann; Guttmann, Katja; Poeggel, Gerd; Braun, Anna Katharina
In: Brain structure & function - Berlin: Springer, 2007, Bd. 222.2017, 8, S. 3639-3651
2016
Peer-reviewed journal article
The transgenerational transmission of childhood adversity - behavioral, cellular, and epigenetic correlates
Gröger, Nicole; Matas, Emmanuel; Gos, Tomasz; Lesse, Alexandra; Poeggel, Gerd; Braun, Anna Katharina; Bock, Jörg
In: Journal of neural transmission - Wien [u.a.]: Springer, 1950, Bd. 123.2016, 9, S. 1037-1052
Stress in utero alters neonatal stress-induced regulation of the synaptic plasticity proteins Arc and Egr1 in a sex-specific manner
Gröger, Nicole; Bock, Jörg; Goehler, Daniela; Blume, Nicole; Lisson, Nicole; Poeggel, Gerd; Braun, Anna Katharina
In: Brain structure & function - Berlin : Springer, Bd. 221 (2016), Heft 1, S. 679-685
Early life stress induces attention-deficit hyperactivity disorder (ADHD)-like behavioral and brain metabolic dysfunctions - functional imaging of methylphenidate treatment in a novel rodent model
Bock, Jörg; Breuer, S.; Poeggel, Gerd; Braun, Anna Katharina
In: Brain structure & function - Berlin : Springer, Bd. 222 (2017), Heft 2, S. 765-780
Transgenerational sex-specific impact of preconception stress on the development of dendritic spines and dendritic length in the medial prefrontal cortex
Bock, Jörg; Poeschel, Julia; Schindler, Julia; Börner, Florian; Shachar-Dadon, Alice; Ferdman, Neta; Gaisler-Salomon, Inna; Leshem, Micah; Braun, Anna Katharina; Poeggel, Gerd
In: Brain structure & function - Berlin: Springer, 2007, Bd. 221.2016, 2, S. 855-863
The impact of parent-infant interaction on epigenetic plasticity mediating synaptic adaptations in the infant brain
Matas, Emmanuel; Bock, Jörg; Braun, Anna Katharina
In: Psychopathology: international journal of descriptive and experimental psychopathology, phenomenology and clinical diagnostics - Basel: Karger, 1968, Bd. 49.2016, 4, S. 201-210
2015
Peer-reviewed journal article
Stress in utero - prenatal programming of brain plasticity and cognition
Bock, Jörg; Wainstock, Tamar; Braun, Anna Katharina; Segal, Menahem
In: Biological psychiatry: a journal of psychiatric neuroscience ; a publication of the Society of Biological Psychiatry - Amsterdam [u.a.]: Elsevier Science, 2015
Impact of an additional chronic BDNF reduction on learning performance in an Alzheimer mouse model
Psotta, Laura; Rockahr, Carolin; Gruß, Michael; Kirches, Elmar; Braun, Anna Katharina; Leßmann, Volkmar; Bock, Jörg; Endres, Thomas
In: Frontiers in behavioral neuroscience - Lausanne: Frontiers Research Foundation, Bd. 9.2015, Art.-Nr.58, insges. 10 S.
Early life stress and sex-specific sensitivity of the catecholaminergic systems in prefrontal and limbic regions of Octodon degus
Kunzler, Jan; Braun, Anna Katharina; Bock, Jörg
In: Brain structure & function - Berlin: Springer, Bd. 220.2015, 2, S. 861-868
Non-peer-reviewed journal article
Mechanismen der generationsübergreifenden Transmission belastender Kindheitserfahrungen - theoretischer Hintergrund, Forschungsdesigns und erste Ergebnisse zweier multizentrischer Studien in Deutschland
Brunner, Romuald; Reichl, Corinna; Bermpohl, Felix; Bertsch, Katja; Bock, Jörg; Bödeker, Katja; Firk, Christine; Fuchs, Anna; Führer, Daniel; Gröger, Nicole; Heinz, Andreas; Herpertz-Dahlmann, Beate; Herpertz, Sabine; Dahmen, Brigitte; Hindi Attar, Catherine; Kluczniok, Dorothea; Konrad, Kerstin; Lehmkuhl, Ulrike; Möhler, Eva; Neukel, Corinne; Reck, Corinna; Resch, Franz; Rether, Kathy; Zietlow, Anna-Lena; Ziegenhain, Ute; Schury, Katharina; Karabatsiakis, Alexander; Braun, Anna Katharina; Gündel, Harald; Kindler, Heinz; Buchheim, Anna; Meysen, Thomas; Kolassa, Iris-Tatjana; Fegert, Jörg M.
In: Trauma & Gewalt - Stuttgart : Klett-Cotta, Bd. 9 (2015), Heft 2, S. 134-147, insges. 14 S.
2014
Book chapter
Neuronale Plastizität
Bock, Jörg
In: Selbstmanagement - ressourcenorientiert / Storch , Maja , 5., erweiterte und vollständig überarbeitete Auflage - Bern : Verlag Hans Huber ; Storch, Maja *1958-* . - 2014, S. 66 - 83
Prägung und Individualisierung der Gehirnfunktion - Grundlagenforschung zu epi-genetischen Mechanismen bei der Gehirnentwicklung
Braun, Anna Katharina; Rether, Kathy; Gröger, Nicole; Bock, Jörg
In: "Personalisierte" Psychiatrie - Paradigmenwechsel oder Etikettenschwindel? - Bern: Huber, 2014 . - 2014, S. 54-73
Peer-reviewed journal article
Stress in utero alters neonatal stress-induced regulation of the synaptic plasticity proteins Arc and Egr1 in a sex-specific manner
Gröger, Nicole; Bock, Jörg; Goehler, Daniela; Blume, Nicole; Lisson, Nicole; Poeggel, Gerd; Braun, Anna Katharina
In: Brain structure & function - Berlin : Springer, Bd. 221 (2016), Heft 1, S. 679-685
Perinatal programming of emotional brain circuits - an integrative view from systems to molecules
Bock, Jörg; Rether, Kathy; Gröger, Nicole; Xie, Lan; Braun, Anna Katharina
In: Frontiers in neuroscience - Lausanne : Frontiers Research Foundation - Vol. 8.2014, Art. 11, insgesamt 16 S.
Non-peer-reviewed journal article
Kommentare zu Romanos & Jans (2014). ADHS - an der Nahtstelle von Medizin und Pädagogik. Lernen und Lernstörungen, 3 , 117 - 132
Rothenberger, Lillian Geza; Lauth, Gerhard W.; Ramacher-Faasen, Nicole; Braun, Anna Katharina; Bock, Jörg; Aster, Sigrid; Aster, Matthias; Aster, Michael
In: Lernen und Lernstörungen - Bern: Huber, 2012, Bd. 3.2014, 3, S. 185-202
2013
Book chapter
Neurowissenschaften
Bock, Jörg; Braun, Anna Katharina
In: Erziehung - Stuttgart : Verlag J.B. Metzler ; Andresen, Sabine *1966-* . - 2013, S. 260-265
Peer-reviewed journal article
Sex-specific positive and negative consequences of avoidance training during childhood on adult active avoidance learning in mice
Spröwitz, Almuth; Bock, Jörg; Braun, Anna Katharina
In: Frontiers in behavioral neuroscience - Lausanne : Frontiers Research Foundation - Vol. 7.2013, Art. 143, insgesamt 11 S.
Paternal deprivation affects the functional maturation of corticotropin-releasing hormone (CRH)- and calbindin-D28k-expressing neurons in the bed nucleus of the stria terminalis (BNST) of the biparental Octodon degus
Gos, Tomasz; Schulkin, Jay; Gos, Anna; Bock, Jörg; Poeggel, Gerd; Braun, Anna Katharina
In: Brain structure & function - Berlin : Springer, Bd. 219 (2014), Heft 6, S. 1983-1990
Infant cognitive training preshapes learning-relevant prefrontal circuits for adult learning - learning-induced tagging of dendritic spines
Bock, Jörg; Poeggel, Gerd; Gruss, Michael; Wingenfeld, Katharina; Braun, Anna Katharina
In: Cerebral cortex - Oxford: Oxford Univ. Press, Bd. 24 (2014), 11, S. 2920-30
Early life stress-induced histone acetylations correlate with activation of the synaptic plasticity genes Arc and Egr1 in the mouse hippocampus
Xie, Lan; Korkmaz, Kemal Sami; Braun, Anna Katharina; Bock, Jörg
In: Journal of neurochemistry - Oxford : Wiley-Blackwell, Bd. 125 (2013), Heft 3, S. 457-464
2012
Book chapter
Tierexperimentelle Befunde zum Einfluss von biographisch frühem Stress
Braun, Anna Katharina; Bock, Jörg
In: Kindesmisshandlung: psychische und körperliche Folgen im Erwachsenenalter / Carsten Spitzer, Hans Jörgen Grabe (Hrsg.): psychische und körperliche Folgen im Erwachsenenalter - Stuttgart: Kohlhammer, 2013 . - 2013, S. 22-35
Prä- und postnatale Stresserfahrungen und Gehirnentwicklung
Bock, Jörg; Braun, Anna Katharina
In: Psychotherapie und Neurowissenschaften , 1. Aufl. - Bern : Huber ; Böker, Heinz *1950-* . - 2012, S. 150-164
Prä- und postnatale Stresserfahrungen und Gehirnentwicklung
Bock, Jörg; Braun, Katharina; Braun, Anna Katharina
In: Psychotherapie und Neurowissenschaften , 1. Aufl. - Bern : Huber ; Böker, Heinz *1950-* . - 2012, S. 150-164 [Literaturverzeichnis: Seite 160-164]
Original article in peer-reviewed international journal
Differential changes of metabolic brain activity and interregional functional coupling in prefronto-limbic pathways during different stress conditions: functional imaging in freely behaving rodent pups
Bock, Jörg; Riedel, Anett; Braun, Anna Katharina
In: Frontiers in cellular neuroscience. - Lausanne : Frontiers Research Foundation, Bd. 6.2012, 19, insges. 17 S.
9-Methyl-ß-carboline-induced cognitive enhancement is associated with elevated hippocampal dopamine levels and dendritic and synaptic proliferation
Gruss, Michael; Appenroth, Dorothea; Flubacher, Armin; Enzenberger, Christoph; Bock, Jörg; Fleck, Christian; Gille, Gabriele; Braun, Anna Katharina
In: Journal of neurochemistry. - Oxford : Wiley-Blackwell, Bd. 121.2012, 6, S. 924-931
2011
Original article in peer-reviewed international journal
Tumor suppressor down-regulated in renal cell carcinoma 1 (DRR1) is a stress-induced actin bundling factor that modulates synaptic efficacy and cognition
Schmidt, Mathias V.; Schülke, Jan-Philip; Liebl, Claudia; Stiess, Michael; Avrabos, Charilaos; Bock, Jörg; Wochnik, Gabriela M.; Davies, Heather A.; Zimmermann, Nicole; Scharf, Sebastian H.; Trümbach, Dietrich; Wurst, Wolfgang; Zieglgänsberger, Walter; Turck, Christoph; Holsboer, Florian; Stewart, Michael G.; Bradke, Frank; Eder, Matthias; Müller, Marianne B.; Rein, Theo
In: Proceedings of the National Academy of Sciences of the United States of America: PNAS - Washington, DC: NAS, Bd. 108.2011, 41, S. 17213-17218
The experience-dependent maturation of prefronto-limbic circuits and the origin of developmental psychopathology - implications for the pathogenesis and therapy of behavioural disorders
Braun, Anna Katharina; Bock, Jörg
In: Developmental medicine & child neurology: officially designated journal of the American Academy for Cerebral Palsy - Oxford [u.a.]: Blackwell, Vol. 53.2011, Suppl. s4, S. 14-18
Prenatal stress and neonatal handling induce sex-specific changes in dendritic complexity and dendritic spine density in hippocampal subregions of prepubertal rats
Bock, Jörg; Murmu, Meena Sriti; Biala, Yaarit; Weinstock, Marta; Braun, Anna Katharina
In: Neuroscience - Amsterdam [u.a.]: Elsevier, Bd. 193.2011, S. 34-43
Original article in peer-reviewed periodical-type series
The impact of perinatal stress on the functional maturation of prefronto-cortical synaptic circuits: Implications for the pathophysiology of ADHD?
Bock, Jörg; Braun, Anna Katharina
In: Gene expression to neurobiology and behavior: human brain development and developmental disorders - Amsterdam [u.a.]: Elsevier, S. 155-169, 2011 - (Progress in brain research; 189)
2010
Original article in peer-reviewed international journal
Impaired active avoidance learning in infant rats appears to be related to insufficient metabolic recruitment of the lateral septum
Riedel, Anett; Gruss, Michael; Bock, Jörg; Braun, Anna Katharina
In: Neurobiology of learning and memory . - Amsterdam : Elsevier, Bd. 93.2010, 2, S. 275-282
2009
Original article in peer-reviewed international journal
Impaired active avoidance learning in infant rats appears to be related to insufficient metabolic recruitment of the lateral septum
Riedel, Anett; Gruss, Michael; Bock, Jörg; Braun, Anna Katharina
In: Neurobiology of learning and memory - Orlando, Fla.: Academic Press . - 2009
Neonatal separation stress reduces glial fibrillary acidic protein- and S100ß-Immunoreactive astrocytes in the rat medial precentral cortex
Musholt, Kristina; Cirillo, Giovanni; Cavaliere, Carlo; Bianco, Maria Rosaria; Bock, Jörg; Helmecke, Carina; Braun, Anna Katharina; Papa, Michele
In: Developmental neurobiology . - Hoboken, NJ : Wiley, Bd. 69.2009, 4, S. 203-211
2008
Book chapter
Born to learn - juvenile learning optimizes brain function
Bock, Jörg; Braun, Anna Katharina
In: Neurosciences in music pedagogy , 2. print. - New York, [NY] : Nova Biomedical Books . - 2008
Habilitation
Hirnbiologische Korrelate frühkindlicher emotionaler Erfahrungs- und Lernprozesse
Bock, Jörg
In: Magdeburg, Univ., Fak. für Naturwiss., Habil.-Schr., 2008, Getr. Zählung, graph. Darst., 30 cm
Original article in peer-reviewed international journal
Refinement of dendritic and synaptic networks in the rodent anterior cingulate and orbitofrontal cortex - critical impact of early and late social experience
Bock, Jörg; Murmu, Reena Prity; Ferdman, Neta; Leshem, Micah; Braun, Anna Katharina
In: Developmental neurobiology - Hoboken, NJ: Wiley, Bd. 68 (2008), 5, S. 685-695
Stress-induced synaptic changes in the rat anterior cingulate cortex are dependent on endocrine developmental time windows
Gos, Tomasz; Bock, Jörg; Poeggel, Gerd; Braun, Anna Katharina
In: Synapse - Hoboken, NJ: Wiley-Liss, Bd. 62 (2008), 3, S. 229-232
Original article in peer-reviewed national journal
Hirnstrukturelle Konsequenzen perinataler Stress- und Deprivationserfahrungen
Braun, Anna Katharina; Bock, Jörg
In: Monatsschrift Kinderheilkunde . - Heidelberg : Springer Medizin-Verl., Bd. 156.2008, 7, S. 629-634
2007
Book chapter
Born to learn - juvenile learning optimizes brain function
Bock, Jörg; Braun, Anna Katharina
In: Neurosciences in music pedagogy - New York, NY: Nova Biomedical Books . - 2007
Original article in peer-reviewed international journal
Methylphenidate treatment recovers stress-induced elevated dendritic spine densities in the rodent dorsal anterior cingulate cortex
Zehle, Stefanie; Bock, Jörg; Jezierski, Grzegorz; Gruss, Michael; Braun, Anna Katharina
In: Developmental neurobiology - Hoboken, NJ: Wiley, Bd. 67 (2007), 14, S. 1891-1900
Weaning age, social isolation, and gender, interact to determine adult explorative and social behavior, and dendritic and spine morphology in prefrontal cortex of rats
Ferdman, N.; Murmu, R. P.; Bock, Jörg; Braun, Anna Katharina; Leshem, M.
In: Behavioural brain research: an international journal - Amsterdam ˜[u.a.]œ: Elsevier, Bd. 180 (2007), 2, S. 174-182
Early stress and chronic methylphenidate cross-sensitize dopaminergic responses in the adolescent medial prefrontal cortex and nucleus accumbens
Jezierski, Grzegorz; Zehle, Stefanie; Bock, Jörg; Braun, Anna Katharina; Gruss, Michael
In: Journal of neurochemistry: JNC ; official journal of the International Society for Neurochemistry / chief ed. A.N. Davison ... - Oxford: Wiley-Blackwell, Bd. 103 (2007), 6, S. 2234-2244
2006
Book chapter
Der Einfluss frühkindlicher emotionaler Erfahrungen auf dir Gehirnentwicklung
Bock, Jörg; Braun, Anna Katharina
In: SGA-Syndrom - Saarbrücken : CONTE-VERLAG ; Zabransky, Siegfried . - 2006
Der Einfluss frühkindlicher emotionaler Erfahrungen auf dir Gehirnentwicklung
Bock, Jörg; Braun, Anna Katharina
In: SGA-Syndrom Small for Gestational Age . - Saarbrücken : CONTE-VERLAG, ISBN 3-936950-42-3, 2006
Original article in peer-reviewed international journal
The International Society for Developmental Psychobiology annual meeting symposium - impact of early life experiences on brain and behavioral development
Sullivan, Regina; Wilson, Donald A.; Feldon, Joram; Yee, Benjamin K.; Meyer, Urs; Richter-Levin, Gal; Avi, Avital; Michael, Tsoory; Gruss, Michael; Bock, Jörg; Helmeke, Carina; Braun, Anna Katharina
In: Developmental psychobiology . - New York, NY [u.a.] : Wiley-Interscience Publ., Bd. 48.2006, 7, S. 583-602; Abstract
Changes of spine density and dendritic complexity in the prefrontal cortex in offspring of mothers exposed to stress during pregnancy
Murmu, Meena Sriti; Salomon, Shiri; Biala, Yaarit; Weinstock, Marta; Braun, Anna Katharina; Bock, Jörg
In: European journal of neuroscience . - Oxford : Blackwell Science, Bd. 24.2006, 5, S. 1477-1487
The International Society for Developmental Psychobiology annual meeting symposium - impact of early life experiences on brain and behavioral development
Sullivan, Regina; Wilson, Donald A.; Feldon, Joram; Yee, Benjamin K.; Meyer, Urs; Richter-Levin, Gal; Avi, Avital; Michael, Tsoory; Gruss, Michael; Bock, Jörg; Helmeke, Carina; Braun, Anna Katharina
In: Developmental psychobiology - New York, NY [u.a.] : Wiley, Bd. 48 (2006), Heft 7, S. 583-602
Regional and cellular distribution of the extracellular matrix protein Tenascin-C in the chick forebrain and its role in neonatal learning
Metzger, M.; Bartsch, S.; Bartsch, U.; Bock, Jörg; Schachner, M.; Braun, Anna Katharina
In: Neuroscience - Amsterdam [u.a.] : Elsevier Science, Bd. 141 (2006), Heft 4, S. 1709-1719
Regional and cellular distribution of the extracellular matrix protein Tenascin-C in the chick forebrain and its role in neonatal learning
Metzger, M.; Bartsch, S.; Bartsch, U.; Bock, Jörg; Schachner, M.; Braun, Anna Katharina
In: Neuroscience : an international journal under the editorial direction of IBRO. - Amsterdam [u.a.] : Elsevier Science, Bd. 141.2006, 4, S. 1709-1719
Early neonatal and postweaning social emotional deprivation interferes with the maturation of serotonergic and tyrosine hydroxylase-immunoreactive afferent fiber systems in the rodent nucleus accumbens hippocampus and amygdala
Gos, Thomas; Becker, K.; Bock, Jörg; Malecki, U.; Bogerts, Bernhard; Poeggel, Gerd; Braun, Anna Katharina
In: Neuroscience - Amsterdam ˜[u.a.]œ : Elsevier, Bd. 140 (2006), Heft 3, S. 811-821
Early neonatal and postweaning social emotional deprivation interferes with the maturation of serotonergic and tyrosine hydroxylase-immunoreactive afferent fiber systems in the rodent nucleus accumbens hippocampus and amygdala
Gos, Thomas; Becker, K.; Bock, Jörg; Malecki, U.; Bogerts, Bernhard; Poeggel, Gerd; Braun, Anna Katharina
In: Neuroscience / IBRO, International Brain Research Organization - Amsterdam ˜[u.a.]œ: Elsevier, Bd. 140 (2006), 3, S. 811-821
2005
Article in conference proceedings
Der Einfluss frühkindlicher emotionaler Erfahrungen auf die Gehirnentwicklung.
Bock, Joerg; Braun, Katharina
In: keine Angabe
Original article in peer-reviewed international journal
Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome.
Restivo, Leonardo; Ferrari, Francesca; Passino, Enrica; Sgobio, Carmelo; Bock, Joerg; Oostra, Ben A.; Bagni, Claudia; Ammassari-Teule, Martine
In: Proceedings of the National Academy of science of the United States of America : PNAS [Washington, DC] 102(2005), Nr. 32, S. 11557 - 11562
Experience-induced changes of dendritic spine densities in the prefrontal and sensory cortex : correlation with developmental time windows.
Bock, Joerg; Gruss, Michael; Becker, Susann; Braun, Katharina
In: keine Angabe
Early socio-emotional experience induces expression of the immediate-early gene ARC/ARG 3.1 (activity-regulated cytoskeleton-associated protein/activity-regulated gene) in learning- relevant brain regions of the newborn chick.
Bock, Joerg; Thode, Christian; Hannemann, Oliver; Braun, Katharina; Darlison, M.G.
In: keine Angabe
The chicken immediate-early gene zenk is expressed in the medio-rostral neostriatum/hyperstriatum ventrale, a brain region involved in acoustic imprinting, and is upregulated after exposure to an auditory stimulus.
Thode, Christian; Bock, Joerg; Braun, Katharina; Darlison, M.G.
In: keine Angabe
Experience-induced changes of dendritic spine densities in the prefrontal and sensory cortex: correlation with developmental time windows
Bock, Jörg; Gruss, Michael; Becker, Susann; Braun, Anna Katharina
In: Cerebral cortex . - New York, NY : Oxford Univ. Press, Bd. 15.2005, 6, S. 802-808
2004
Book chapter
Frühkindliche Emotionen steuern die funktionelle Reifung des Gehirns : tierexperimentelle Befunde und ihre mögliche relevanz für die Psychotherapie.
Braun, Katharina; Bock, Joerg
In: keine Angabe
Tierexperimentelle Befunde zu den hirnstrukturellen Folgen früher Stresserfahrungen.
Braun, Katharina; Helmeke, Carina; Bock, Joerg; Poeggel, Gerd
In: keine Angabe
2003
Original article in peer-reviewed international journal
Haloperidol impairs auditory filial imprinting and modulates monoaminergic neurotransmission in an imprinting-relevant forebrain area of the domestic chick.
Gruss, Michael; Bock, Joerg; Braun, Katharina
In: keine Angabe
Original article in peer-reviewed national journal
Frühkindliche emotionale Erfahrungen beeinflussen die funktionelle Entwicklung des Gehirns.
Bock, Joerg; Helmeke, Carina; Ovtscharoff, Wladimir; Gruss, Michael; Braun, Katharina
In: keine Angabe
Die Narben der Kindheit.
Braun, Katharina; Bock, Joerg
In: keine Angabe
2002
Book chapter
Frühe emotionale Erfahrungen und ihre Relevanz für die Entstehung und Therapie psychischer Erkrankungen.
Braun, Katharina; Bock, Joerg; Gruss, Michael; Helmeke, Carina; Ovtscharoff, Wladimir; Schnabel, Reinhild; Ziabreva, Irina; Poeggel, Gerd
In: keine Angabe
Original article in peer-reviewed national journal
Frühkindliche Emotionen steuern die funktionelle Reifung des Gehirns : Tierexperimentelle Befunde und ihre mögliche Relevanz für die Psychotherapie.
Bock, Joerg; Braun, Katharina
In: keine Angabe
- Animal Models for Mental Disorders (Depression, ADHD)
- Developmental Neurobiology
- Learning & Memory
- Behavioral Pharmacology
- Functional Imaging
- Quantitative Neuromorphology
- Immunohistochemistry
- Molecular Biology
- Epigenetics